The NISN Organization is comprised of three main groups: Customer Interface, Business Management, and Network Services. Russian Project Management provides management of local and in-country support for Russia services. IT Security and Contract Management provide overall services to the Organization.

Center Customer Commitment Managers (CCCM) and NISN Center/Program Representatives are NASA employees who act as liaisons between NISN and their Center or Program.

Service Owners are NASA employees who are responsible for the end-to-end delivery of the service.

International partners work with NISN to provide support for cooperative efforts.